The Helios billing system is designed around a pharmacy-first model, streamlining the process for partner pharmacies and ensuring flexibility in patient and insurer billing. Under this approach, Helios provides its partners with a base cost for products. Following this, the pharmacy takes on the responsibility of billing the patient or their insurance provider, adhering to their established dispensing protocols. Pharmacy pricing typically involves several components. Beyond the base cost supplied by Helios, pharmacies commonly incorporate a dispensing fee and apply a markup, which often ranges from 10–15% and can vary based on individual pharmacy policies. This structure allows pharmacies to maintain their operational profitability while offering Helios products. A crucial aspect of this model involves insurance considerations, especially for compounded preparations. Unlike standard DIN-based products, compounds often have a different processing pathway with insurers. To facilitate the recognition and processing of claims for compounded preparations, pharmacies may utilize a mixture file or a substitute mixture file within their systems. This ensures that insurers correctly identify the preparation as a compound. Helios further supports this process by providing comprehensive documentation, including detailed invoices and mixture breakdowns, which are vital for supporting audits and ensuring smooth claim processing. This robust documentation helps both pharmacies and insurers manage the unique aspects of compounded medication claims effectively.